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The 52:52:52 project, launching both on this site and on social media in early 2024 will help you address 52 issues with 52 responses over 52 weeks.

A Mundane Comedy is Dominic Kelleher's new book, which will be published in mid 2024. The introduction is available here and further extracts will appear on this site and on social media in the coming months.

This site addresses what's changing, in our own lives, in our organisations, and in wider society. You'll learn about key changes across more than 150 areas, ranging from ageing and time, through nature and animals, to kindness and love...and very much else inbetween.

Halcyon's aim is to help you reflect on how you can better deal with related change in your own life.

What's Changing? - Alternative



Please see below selected recent alternative lifestyle-related change.


See also:


January 2024

  • Psychedelic drugs such as MDMA and psilocybin, the hallucinogenic compound found in magic mushrooms, have promised to revolutionise psychiatric treatments. A small trial in military veterans suggested that a lesser-known, potent psychedelic drug called ibogaine could be used to treat traumatic brain injury (TBI). One month after ibogaine treatment, the veterans reported that TBI symptoms such as post-traumatic stress disorder (PTSD) and depression had decreased by more than 80%, on average1.


December 2023

  • Further reading:


November 2023


April 2023

  • Researchers gave healthy subjects potent, intravenous doses of the psychedelic DMT and observed their brains with both functional MRI and electroencephalography. They then witnessed the brain's hierarchical organisation collapse, to be replaced by a state of "global hyperconnectivity". Brain entropy, defined as "the number of neural states a given brain can access," skyrocketed.
  • Research claimed that people in Spain were getting high on hallucinogenic drugs derived from plants 3,000 years ago, the oldest direct evidence of narcotics use on the European continent.


March 2023

  • The clinical evidence for using psychedelics to treat major mental health conditions is building, but despite the growing data, we don't know just how psychedelics might be helping. One theory behind conditions like depression is that they’re caused by the breakdown of connections between brain cells. Researchers have found, in multiple studies, that psychedelics can increase connections between cortical neurons - specifically, they spark growth of the tendril-y antennae on neurons, called dendrites, that catch signals from other brain cells. In theory, this may mean new connections being formed and strengthened, helping the brain to rewire itself.


December 2022


August 2022

  • The FT noted that, in recent years, microdosing psychedelics has become more mainstream, and some business leaders and HR professionals are evangelising ketamine-assisted therapy as an increasingly popular health benefit for employees. Ketamine is legal for medical use in the US and UK, and while it’s most widely used as an anaesthetic, studies have found ketamine is useful in treating depression and other mental illness. As rates of mental illness increased by more than 25% in the first year of the pandemic, according to a recent report by the World Health Organisation, ketamine-assisted therapy gained popularity as a mental health treatment.


June 2022


October 2021


September 2021


July 2021


May 2021


October 2020

  • Synthesis is an Amsterdam-based wellness retreat claiming to offer the world’s first commercial psychedelic depression therapy. The treatment is medically supervised by  a leading clinical psychologist at Imperial College London’s Centre for Psychedelic Research, who uses psilocybin-infused truffles, which are related to magic mushrooms and legal in the Netherlands. Patients enter a 13-month course that includes monthly group therapy and a five-day retreat with two psilocybin sessions. Since the release of a groundbreaking study in 2016, more and more scientific research points at the medicinal and therapeutic benefits that psychedelic mushrooms can have on patients suffering from depression and other mental illnesses. A commonly cited reason for why psilocybin, the main psychoactive component of magic mushrooms, can be so effective is that it can ‘unshackle’ patients’ minds - enabling them to see things in a different way, consequently leading to lasting shifts in their mindsets.


December 2018


October 2018


September 2018


August 2018